教育和工作简历

2020.10-至今，云南农业大学，教授，化学系

2018.01-2020.9，云南农业大学，副教授，化学系

2015.08-2017.12，云南农业大学，博士见习

学术兼职

中国化学学会会员

云南省微生物协会会员

食品安全风险评估委员

教学工作

研究生课程：食品营养学研究进展、细胞及分子生物学实验技术、现代食品营养学

本科生课程：有机化学、有机化学I、有机化学II、应化Seminar、有机化学实验、应用高分子化学、仪器分析实验、普通化学、普通化学实验

研究方向

农业化学基础研究及应用

食药同源化学物质基础及生物学功效

天然多糖化学生物学及其应用基础研究

管理服务工作

副院长

奖励与荣誉

云南省“兴滇英才”计划青年人才（2020年）

研究项目

国家自然科学地区基金项目“新型铁皮石斛素类微管蛋白抑制剂的挖掘及作用机理研究”（编号：31960075）, 2020.01–2023.12, 项目负责人

国家自然科学基金青年项目“表没食子儿茶素没食子酸酯（EGCG）氧化物的选择性合成、分离及抗肿瘤活性研究”（编号：21602196），2017.01–2019.12，项目负责人

云南省农业联合专项重点项目“茶多酚纳米聚集体功能化TKIs的构建及其在靶向治疗非小细胞肺癌的应用研究”（编号：202101BD070001-028），2022.01–2024.12，项目负责人

云南省农业联合专项面上项目“儿茶素类化合物的化学修饰对其生物利用度屏障的作用及机理研究”（编号：2017FG001（-046）），2017.09–2020.08，项目负责人

云南省自然科学基金青年项目“化学选择性EGCG偶联氧化产物的合成及抗肿瘤活性研究”（ 编号：2017FD084），2017.06–2020.05，项目负责人

代表性论文

Yan-Ping Huang#, Xiang-Dan Cuan#, Wei-wei Zhu, Xing-Ying Yang, Yun-Li Zhao, Jun Sheng, Cheng-Ting Zi*, Xuan-Jun Wang*. An EGCG Derivative in Combination with Nimotuzumab for the Treatment of Wild-Type EGFR NSCLC. Int. J. Mol. Sci. 2023, 24 (18), 14012.

Jia-Min Xian#, Hong-Tao Hu#, Shu Yang#, Yu-Na Wang, Zhuo-Yi Wang, Ruo-Han Zhang, Cheng-Ting Zi*, Pei-Yuan Sun*, Jing Wang*. Inhibitory Effect of Magnolol on Activation of EGFR L858R/T790M/G796R. BJSTR., 2023, 50 (3), 41660-41666.

Liu Yang#, ChengTing Zi#, Ding-Kang Chen, Jin-Yu Li, Rui He, Jiang-Miao Hu*. Target acquisition of anti-aging manno-oligosaccharide that triggers ECM process via TGF-β/Smads-SIRT1 signalling pathway. Carbohyd. Polym. 2022, 22, 120380.

Cheng-Ting Zi#, Yin-Rong Xie#, Yun Niu#, Zhen-Hao Liu, Liu Yang, Yong-Kai Xi, Zhen-Jie Li, Feng-Mei Zhang, Ze-Min Xiang*, Jun Sheng*. Novel cannabidiol (CBD) derivatives: Synthesis, anti-inflammatory activity, and molecular docking. Phytochem. Lett. 2022, 51, 97–103.

Xiu-Li Sun#, Ze-Min Xiang#, Yin-Rong Xie#, Ning Zhang, Li-Xia Wang, Yi-Long Wu, Dong-Ying Zhang, Xuan-Jun Wang*, Jun Sheng*, Cheng-Ting Zi*. Dimeric-(-)-eigallocatechin-3-gallate inhibits the proliferation of lung cancer cells by inhibiting the EGFR signaling pathway. Chem-Biol. Interact. 2022, 365, 110084.

Yan-Ping Huang#, Xiang-Dan Cuan#, Xing-Ying Yang, Wei-Wei Zhu, Yun-Li Zhao, Li Jiang, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Oxidized tea polyphenol (OTP-3) targets EGFR synergistic nimotuzumab at inhibition of non-small cell lung tumor growth. Bioorg. Chem. 2022, 128, 106084.

Si-Si Chen#, Liu Yang#, Xia Qu#, Jin-Yu Li#, Cheng-Ting Zi, Hao Wang*, Jiang-Miao Hu*, Ye Liu*. A new polysaccharide platform constructs self-adjuvant nanovaccines to enhance immune responses. J. Nanobiotechnol. 2022, 20, 320.

Ye-Wei Huang#, Jing-Yun Yan#, Xiu-Li Sun#, Yun Niu, Wen-Jun Yuan, Ling-Bin Kong, Xiang-Dong Qin, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Anticancer effects of dendrocandin (DDCD) against AKT in Hpeg2 cells using Molecular Modeling, DFT and in Vitro Study. Struct. Chem. 2022, 33, 1331–1340.

Ning Zhang#, Yi-Long Wu#, Miao Qiao, Wen-Juan Yuan, Xing-Yu Li, Xuan-Jun Wang*, Jun Sheng*, Cheng-Ting Zi*. Structure–antioxidant activity relationships of dendrocandin analogues determined using density functional theory. Struct. Chem. 2022, 33, 795–805.

Li-Xia Wang#, Ze-Hao Wang, Xiu-Li Sun, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Discovery of EGFR-Targeted Environment-Sensitive Fluorescent Probes for Cell Imaging and Efficient Tumor Detection. Bioorg. Chem. 2022. 121, 105585.Published: 2022-01-04

Ya Wang#, Xiao-Jing Shen#, Fa-Wu Su#, Yin-Rong Xie, Li-Xia Wang, Ning Zhang, Yi-Long Wu , Yun Niu, Dong-Ying Zhang, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng. Novel per-butyrylated glucoses derivatives of (-)-epigallocatechin-3-gallate inhibit cancer cells proliferation by decreasing phosphorylation of the EGFR: Synthesis, cytotoxicity and molecular docking. Molecules. 2021, 26 (14) 4361.

Cheng-Ting Zi#, Ze-Hao Wang#, Jing Shi#, Boya Shi, Ning Zhang, Yi-Ling Wu, Yin-Rong Xie, Lu Zhou, Chun Xiao*, Xuan-Jun Wang*, Jun Sheng*. Synthesis, cytotoxicity and molecular docking of methylated (-)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin derivatives as novel antitumor agents. J. Chem. Res. 2021:1–7.

Ze-Hao Wang#, Li-Xia Wang#, Bo-Ya Shi, Xiu-Li Sun, Yin-Rong Xie, Hao-Nan Yang, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Demethyleneberberine promotes apoptosis and suppresses TGF-β/Smads induced EMT in the colon cancer cells HCT-116. Cell Biochem. Fun. 2021: 1–8.

Bo-Ya Shi#, Ze-Hao Wang#, Ning Zhang, Yin-Rong Xie, Xiu-Li Sun, Hao-Nan Yang, Yi-Long Wu, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Synthesis and Anticancer Activity of Glucosylated novel (-)-Epigallocatechin-3-gallate Derivatives Linked via Triazole Rings. Med. Chem. Res. 2021, 30: 1240–1248.

Jing-Yun Yan#, Hao-Nan Yang#, Ning Yang, Yin-Rong Xie, Xiu-Li Sun, Ye-Wei Huang, Cheng-Ting Zi*, Xuan-Jun Wang*, Jun Sheng*. Synthesis and in vitro biological evaluation of novel dendrocandin analogue as potential anti-tumor agent. Nat. Prod. Res. 2021:1–6.

Boya Shi, Zehao Wang, Xuanjun Wang, Jun Sheng*, Chengting Zi*. Recent progress of small-molecule epidermal growth factor receptor (EGFR) inhibitors. Med. Res. 20202020, 4 (200011), 1–4.

Canpeng Li#, Yuxun Lu#, Chengting Zi#, Yuting Zhao, Hui Zhao*, Yaping Zhang*. Cationic pillar[6]arene induces cell apoptosis by inhibiting protein tyrosine phosphorylation via host-guest recognition. Int. J. Mol. Sci. 2020, 21, 7949.

Chengting Zi#, Liu Yang#, Yue Hu, Pan Zhang, Han Tang, Banglei Zhang, Xiaojing Shen, Qinghua Kong, Ya Wang*, Xuanjun Wang*, Jun Sheng*. Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4β-triazolopodophyllotoxin conjugates. J. Asin Nat. Prod. Res. 2021, 23 (8), 772-780.

Chengting Zi#, Peiyuan Sun#, Ning Zhang, Han Tang, Haonan Yang, Qi Wang, Yuna Wang, Jing Wang*, Xuanjun Wang*, Jun Sheng*. Glucosylated (-)-Epigallocatechin-3-gallate (EGCG) derivative via triazole ring: Synthesis and combined with cisplatin/paclitaxel inhibits NSCLC cancer cells by decreasing phosphorylation of the EGFR. J. Chem. Res. 2020, 44 (9-10) 586–591.

Yuna Wang#, Jing Wang#, Hao-Nan Yang, Bang-Lei Zhang, Pan Zhang, Pei-Yuan Sun, Ning Zhang, Ya Wang, Jun Sheng*, Xuan-Jun Wang*, Cheng-Ting Zi*. The oxidation of (-)-epigallocatechin-3-gallate inhibits T-Cell Acute Lymphoblastic Leukemia cell line HPB-ALL via the regulation of Notch1 expression. RSC Adv. 2020, 10, 1679–1684.

代表性著作

参编《有机化学》

参编《普通化学与定量分析化学学习指导及习题解答》等书

专利及标准

盛军，王宣军，字成庭，王晶，向泽敏，黄业伟，王娅，吴晓云，方崇业，刘佳，张冬英，汪琦，唐晗，张帮磊，王玉娜.表没食子儿茶素没食子酸酯糖苷衍生物及其应用，专利公开号：CN201810094218.6

盛军，王宣军，黄艳苹，字成庭，向泽敏，黄业伟，赵云丽，爨向丹，徐欢欢，罗瑞. 表没食子儿茶素没食子酸酯糖苷衍生物及其应用，专利公开号：CN 110038006 A

字成庭，盛军，王宣军，燕静云，杨豪男，张帮磊，胡月，杨宁，张宁，吴以龙.铁皮石斛素类似物及其制备方法和用途.专利公开号：CN 112266377 A

字成庭，盛军，王宣军，张宁，杨豪男，袁文娟，乔妙，孙秀丽.一种铁皮石斛素及其制备方法.专利公开号：CN 113045536

盛军，字成庭，王宣军，袁文娟，孙秀丽，张帮磊，杨豪男，谢引荣，燕静云，胡月，张宁，杨宁.铁皮石斛素及其制备抗癌药物的应用.专利公开号：CN 112979608 A

盛军，字成庭，王宣军，袁文娟，孙秀丽，谢引荣，杨豪男，王丽霞，张宁，吴以龙，施博雅，王泽昊.铁皮石斛素及其用途.专利公开号：CN 112939928 A

字成庭，盛军，王宣军，张宁，吴以龙.一种用于电化学工作站检测的多功能电解池.专利号：ZL 2020 2 2833997.2申请时间：2020.12.01授权时间：2021.10.19

字成庭，盛军，王宣军，吴以龙，张宁.一种用于分离茶多糖和聚合多酚的装置.专利号：ZL 2020 2 3008416.8

学生工作

指导已经毕业研究生5名，在读研究生5名，发表论文22篇。

指导本科生30名，本科生与发表科研论文8篇。