解静,女,1988年生,博士,副教授,硕士研究生导师。
研究方向:天然产物健康功能研究、营养调控与肠道微生物。
教学情况:承担本科生《食品化学》、《食品质量原理与应用》、《食品新资源开发利用》;硕士生《技术与产品研发专题》课程教学工作。
主持项目:
(1)云南省科技厅,基础研究面上项目,202201AT070262,基于微生物-肠-脑轴探讨辣木异硫氰酸酯降脂的分子机制, 2022-06至2025-05,10万元,在研,主持;
(2)云南省科技厅,农业基础研究联合专项面上项目,202101BD070001-120肠道微生物介导的核桃活性肽缓解结肠炎作用机制研究,2022-01至2024-12,10万元,在研,主持;
(3)云南省科技厅,农业基础研究联合专项青年项目,2018FG001-088,辣木生物碱对人非小细胞肺癌A549细胞的抑制作用及机理研究,2019-01至2022-01,5万元,结题,主持;
(4)云南省科技厅,重大科技专项计划子课题,202002AA100005-4-5,基于多组学的辣木籽多肽缓解结肠炎作用机制研究,2022-01至2022-12,10万元,在研,主持;
(5)云南省科技厅,云南绿色食品国际合作研究中心子课题,2019AG00905003,核桃油靶向调节肠道菌群调控血糖稳态机制研究及产品开发, 2019-07至2021-12,20万元,在研,主持;
(6)云南省教育厅,科学研究基金项目,2019J0180,辣木生物碱通过调节COX2蛋白抑制PC3前列腺癌细胞增殖和迁移的研究,2019-01至2020-12,4万元,结题,主持;
(7)云南农业大学,博士科研启动项目,A2032002450,4-(α-L-鼠李糖基)-异硫氰酸苄酯对人肾癌细胞的生长抑制作用及其作用机制研究,2019-01至2023-12,10万元,在研,主持;
(8)云南省高原特色农业产业研究院,科学研究基金项目,Y-201807-002,辣木叶石油醚提取物抑制高脂饮食诱导的肥胖及作用机制研究,2018-07至2020-07,4.5万元,结题,主持。
代表性论文(SCI):
(1) Jing Xie*; Ling-Fei Li*; Tian-Yi Dai; Xin Qi; Yan Wang; Tiao-Zhen Zheng; Xiao-Yu Gao; Yun-Juan Zhang; Yu Ai; Li Ma; Song-Lin Chang; Feng-Xian Luo; Yang Tian#; Jun Sheng #; Short-Chain Fatty Acids Produced by Ruminococcaceae Mediate α-Linolenic Acid Promote Intestinal Stem Cells Prolife ration, Molecular Nutrition & Food Research, 2022, 66(1): e2100408. (2区,TOP,IF=5.914)
(2) Zi-Shan Hong*, Jing Xie*, Xue-Feng Wang, Jing-Jing Dai, Jia-Ying Mao, Yu-Ying Bai, Jun Sheng#, Yang Tian#. Moringa oleifera Lam. Peptide Remodels Intestinal Mucosal Barrier by Inhibiting JAK-STAT Activation and Modulating Gut Microbiota in Colitis. Front Immunol. 2022 Jul 15;13:924178. (2区,TOP,IF=8.786)
(3) Jing Xie*; Ying-Yan Qian*; Yang Yang; Lin-Jie Peng; Jia-Ying Mao; Ming-Rong Yang; Yang Tian#; Jun Sheng#; Isothiocyanate From Moringa oleifera Seeds Inhibits the Growth and Migration of Renal Cancer Cells by Regulating the PTP1B-dependent Src/Ras/Raf/ERK Signaling Pathway, Frontiers in Cell and Developmental Biology , 2022, 9: 790618. (2区,IF=6.684)
(4) Jing Xie*; Feng-Xian Luo*; Chong-Ying Shi; Wei-Wei Jiang; Ying-Yan Qian; Ming-Rong Yang; Shuang Song; Tian-Yi Dai; Lei Peng; Xiao-Yu Gao; Liang Tao; Yang Tian#; Jun Sheng#; Moringa oleifera Alkaloids Inhibited PC3 Cells Growth and Migration Through the COX-2 Mediated Wnt/beta-Catenin Signaling Pathway, Frontiers in Pharmacology , 2020, 11: 523962. (2区,IF=4.225)
(5) Jing Xie*; Yan Wang*; Wei-Wei Jiang*; Xuan-Fei Luo; Tian-Yi Dai; Lei Peng; Shuang Song; Ling-Fei Li; Liang Tao; Chong-Ying Shi; Ruo-Shi Hao; Rong Xiao; Yang Tian#; Jun Sheng#; Moringa oleife ra Leaf Petroleum Ether Extract Inhibits Lipogenesis by Activating the AMPK Signaling Pathway, Frontiers in Pharmacology , 2018, 9: 1447. (2区,IF=3.831)
(6) Jing Xie; Hai-Shuang Yu; Shuang Song; Chong-Ye Fang; Xuan-Jun Wang; Zhong-Bin Bai; Xiao Ma; Shu-Mei Hao; Hong-Ye Zhao#; Jun Sheng#; Pu-erh Tea Water Extract Mediates Cell Cycle Arrest and Apoptosis in MDA-MB-231 Human Breast Cancer Cells, Frontiers in Pharmacology , 2017, 8: 190. (2区,IF=4.40)
(7) Jing Xie; Lin-Jie Peng; Ming-Rong Yang; Wei-Wei Jiang; Jia-Ying Mao; Chong-Ying Shi; Yang Tian#; Jun Sheng#; Alkaloid Extract of Moringa oleifera Lam. Exerts Antitumor Activity in Human Non-Small-Cell Lung Cancer via Modulation of the JAK2/STAT3 Signaling Pathway. Evidence-based complementary and alternative medicine. 2021 Jun 8; 2021:5591687. (4区,IF=2.629)
著作/教材:
(1)参编专著《现代辣木生物学》,云南科技出版社,2015;
(2)参编专著《MODERN MORINGA OLEIFERA LAM. BIOLOGY》,云南科技出版社,2015。